Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS

• المؤلفون الرئيسيون: Zhu, Xiaoyang, Guo, Yangyang, Liu, Zhigang, Yang, Jingyi, Tang, Huiru, Wang, Yulan
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Medicine; Adaptive Immunity; Antimicrobial Responses
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/153799
• المؤسسة: Nanyang Technological University

Itaconic acid is produced by immune responsive gene 1 (IRG1)-coded enzyme in activated macrophages and known to play an important role in metabolism and immunity. In this study, mechanism of itaconic acid functioning as an anti-inflammatory metabolite was investigated with molecular biology and immu...