TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus

• المؤلفون الرئيسيون: Jayaraman, Anusha, Htike, Thein Than, James, Rachel, Picon, Carmen, Reynolds, Richard
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Medicine; Necroptosis; Alzheimer’s Disease
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/153812

The pathogenetic mechanisms underlying neuronal death and dysfunction in Alzheimer's disease (AD) remain unclear. However, chronic neuroinflammation has been implicated in stimulating or exacerbating neuronal damage. The tumor necrosis factor (TNF) superfamily of cytokines are involved in many...