Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore

• Main Authors: Wang, Bei, Goh, Yun Shan, Prince, Tessa, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Hor, Pei Xiang, Loh, Chiew Yee, Fong, Siew Wai, Hartley, Catherine, Tan, Seow-Yen, Young, Barnaby Edward, Leo, Yee Sin, Lye, David Chien Boon, Maurer-Stroh, Sebastian, Ng, Lisa F. P., Hiscox, Julian A., Renia, Laurent, Wang, Cheng-I
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Antibodies; Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
• Online Access: https://hdl.handle.net/10356/153825
• Institution: Nanyang Technological University

The rapid spreading of SARS-CoV-2 variants B.1.1.7 originated from the United Kingdom and B.1.351 from South Africa has contributed to the second wave of COVID-19 cases in the respective countries and also around the world. In this study, we employed advanced biochemical and virological methodologie...