Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants

Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants

Biofilms disperse in response to specific environmental cues, such as reduced oxygen concentration, changes in nutrient concentration and exposure to nitric oxide. Interestingly, biofilms do not completely disperse under these conditions, which is generally attributed to physiological heterogeneity...

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Bibliographic Details
Main Authors: Nair, Harikrishnan A. S., Subramoni, Sujatha, Poh, Wee Han, Nabilah Taqiah Hasnuddin, Tay, Martin, Givskov, Michael, Tolker-Nielsen, Tim, Kjelleberg, Staffan, McDougald, Diane, Rice, Scott A.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Bioflm Development
Bioreporter
Online Access:https://hdl.handle.net/10356/153950
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Institution: Nanyang Technological University
Language: English
Description
Summary:Biofilms disperse in response to specific environmental cues, such as reduced oxygen concentration, changes in nutrient concentration and exposure to nitric oxide. Interestingly, biofilms do not completely disperse under these conditions, which is generally attributed to physiological heterogeneity of the biofilm. However, our results suggest that genetic heterogeneity also plays an important role in the non-dispersing population of P. aeruginosa in biofilms after nutrient starvation.

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