Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants

Biofilms disperse in response to specific environmental cues, such as reduced oxygen concentration, changes in nutrient concentration and exposure to nitric oxide. Interestingly, biofilms do not completely disperse under these conditions, which is generally attributed to physiological heterogeneity...

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Main Authors:	Nair, Harikrishnan A. S., Subramoni, Sujatha, Poh, Wee Han, Nabilah Taqiah Hasnuddin, Tay, Martin, Givskov, Michael, Tolker-Nielsen, Tim, Kjelleberg, Staffan, McDougald, Diane, Rice, Scott A.
Other Authors:	School of Biological Sciences
Format:	Article
Language:	English
Published:	2022
Subjects:	Science::Biological sciences Bioflm Development Bioreporter
Online Access:	https://hdl.handle.net/10356/153950
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Institution:	Nanyang Technological University
Language:	English

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spelling	sg-ntu-dr.10356-1539502022-06-11T20:11:27Z Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants Nair, Harikrishnan A. S. Subramoni, Sujatha Poh, Wee Han Nabilah Taqiah Hasnuddin Tay, Martin Givskov, Michael Tolker-Nielsen, Tim Kjelleberg, Staffan McDougald, Diane Rice, Scott A. School of Biological Sciences Interdisciplinary Graduate School (IGS) Singapore Centre for Environmental Life Sciences and Engineering (SCELSE) Science::Biological sciences Bioflm Development Bioreporter Biofilms disperse in response to specific environmental cues, such as reduced oxygen concentration, changes in nutrient concentration and exposure to nitric oxide. Interestingly, biofilms do not completely disperse under these conditions, which is generally attributed to physiological heterogeneity of the biofilm. However, our results suggest that genetic heterogeneity also plays an important role in the non-dispersing population of P. aeruginosa in biofilms after nutrient starvation. Ministry of Education (MOE) Nanyang Technological University National Research Foundation (NRF) Published version The authors would like to acknowledge the fnancial support from National Research Foundation and Ministry of Education Singapore under its Research Centre of Excellence Program, a grant from the Singapore Ministry of Educa‑ tion (MOE2019-T2–1-050) and Nanyang Technological University for research scholarship for HASN. Funding was also provided through the Australian Research Council (DP140102192). 2022-06-06T05:31:22Z 2022-06-06T05:31:22Z 2021 Journal Article Nair, H. A. S., Subramoni, S., Poh, W. H., Nabilah Taqiah Hasnuddin, Tay, M., Givskov, M., Tolker-Nielsen, T., Kjelleberg, S., McDougald, D. & Rice, S. A. (2021). Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants. BMC Microbiology, 21(1), 255-. https://dx.doi.org/10.1186/s12866-021-02318-8 1471-2180 https://hdl.handle.net/10356/153950 10.1186/s12866-021-02318-8 34551714 2-s2.0-85115311723 1 21 255 en MOE2019-T2-1-050 BMC Microbiology © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Science::Biological sciences Bioflm Development Bioreporter
spellingShingle	Science::Biological sciences Bioflm Development Bioreporter Nair, Harikrishnan A. S. Subramoni, Sujatha Poh, Wee Han Nabilah Taqiah Hasnuddin Tay, Martin Givskov, Michael Tolker-Nielsen, Tim Kjelleberg, Staffan McDougald, Diane Rice, Scott A. Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants
description	Biofilms disperse in response to specific environmental cues, such as reduced oxygen concentration, changes in nutrient concentration and exposure to nitric oxide. Interestingly, biofilms do not completely disperse under these conditions, which is generally attributed to physiological heterogeneity of the biofilm. However, our results suggest that genetic heterogeneity also plays an important role in the non-dispersing population of P. aeruginosa in biofilms after nutrient starvation.
author2	School of Biological Sciences
author_facet	School of Biological Sciences Nair, Harikrishnan A. S. Subramoni, Sujatha Poh, Wee Han Nabilah Taqiah Hasnuddin Tay, Martin Givskov, Michael Tolker-Nielsen, Tim Kjelleberg, Staffan McDougald, Diane Rice, Scott A.
format	Article
author	Nair, Harikrishnan A. S. Subramoni, Sujatha Poh, Wee Han Nabilah Taqiah Hasnuddin Tay, Martin Givskov, Michael Tolker-Nielsen, Tim Kjelleberg, Staffan McDougald, Diane Rice, Scott A.
author_sort	Nair, Harikrishnan A. S.
title	Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants
title_short	Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants
title_full	Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants
title_fullStr	Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants
title_full_unstemmed	Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants
title_sort	carbon starvation of pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants
publishDate	2022
url	https://hdl.handle.net/10356/153950
_version_	1735491075229876224

Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants

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