Sex-specific accelerated decay in time/activity-dependent plasticity and associative memory in an animal model of Alzheimer's disease

• Main Authors: Navakkode, Sheeja, Gaunt, Jessica Ruth, Pavon, Maria Vazquez, Bansal, Vibhavari Aysha, Abraham, Riya Prasad, Chong, Yee Song, Ch'ng, Toh Hean, Sajikumar, Sreedharan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Alzheimer's Disease; Behavioural Tagging
• Online Access: https://hdl.handle.net/10356/153998
• Institution: Nanyang Technological University

Clinical studies have shown that female brains are more predisposed to neurodegenerative diseases such as Alzheimer's disease (AD), but the cellular and molecular mechanisms behind this disparity remain unknown. In several mouse models of AD, synaptic plasticity dysfunction is an early event an...