Epigenetics: the panacea for cognitive decline?

by Sharma, Mahima, Raghuraman, Radha, Sajikumar, Sreedharan
Published 2022

Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress

by Raghuraman, Radha, Navakkode, Sheeja, Sajikumar, Sreedharan
Published 2024

Activation of microglia in acute hippocampal slices affects activity-dependent long-term potentiation and synaptic tagging and capture in area CA1

by Raghuraman, Radha, Karthikeyan, Aparna, Wei, Wong Lik, Dheen, S Thameem, Sajikumar, Sreedharan
Published 2020

Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats

by Saw, Genevieve, Krishna, Kumar, Gupta, Neelima, Soong, Tuck Wah, Mallilankaraman, Karthik, Sajikumar, Sreedharan, Dheen, S Thameem
Published 2020

ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing A beta impairment of insulin signaling in an Alzheimer's disease mouse model

by Chan, Elizabeth S, Shetty, Mahesh Shivarama, Sajikumar, Sreedharan, Chen, Christopher, Soong, Tuck Wah, Wong, Boon-Seng
Published 2022

Inhibition of lysine methyltransferase G9a/GLP reinstates long-term synaptic plasticity and synaptic tagging/capture by facilitating protein synthesis in the hippocampal CA1 area o...

by Han, Javan Lee Tze, Pang, Karen Ka Lam, Ang, Sheila Rui Xia, Sharma, Mahima, Sajikumar, Sreedharan
Published 2022

Inactive variants of death receptor p75(NTR) reduce Alzheimer's neuropathology by interfering with APP internalization (vol 40, e104450, 2021)

by Yi, Chenju, Goh, Ket Yin, Wong, Lik-Wei, Ramanujan, Ajeena, Tanaka, Kazuhiro, Sajikumar, Sreedharan, Ibanez, Carlos F
Published 2022

Sex-specific accelerated decay in time/activity-dependent plasticity and associative memory in an animal model of Alzheimer's disease

by Navakkode, Sheeja, Gaunt, Jessica Ruth, Pavon, Maria Vazquez, Bansal, Vibhavari Aysha, Abraham, Riya Prasad, Chong, Yee Song, Ch'ng, Toh Hean, Sajikumar, Sreedharan
Published 2022

Sex-specific accelerated decay in time/activity-dependent plasticity and associative memory in an animal model of Alzheimer's disease

by Navakkode, Sheeja, Gaunt, Jessica Ruth, Pavon, Maria Vazquez, Bansal, Vibhavari Aysha, Abraham, Riya Prasad, Chong, Yee Song, Ch'ng, Toh Hean, Sajikumar, Sreedharan
Published 2022

Distinct contributions of ventral CA1/amygdala co-activation to the induction and maintenance of synaptic plasticity

by Chong, Yee Song, Wong, Lik-Wei, Gaunt, Jessica, Lee, Yan Jun, Goh, Cai Shan, Morris, Richard GM, Ch'ng, Toh Hean, Sajikumar, Sreedharan
Published 2023

Biomimicking fiber platform with tunable stiffness to study mechanotransduction reveals stiffness enhances oligodendrocyte differentiation but impedes myelination through YAP-depen...

by Ong, William, Marinval, Nicolas, Lin, Junquan, Nai, Mui Hoon, Chong, Yee-Song, Pinese, Coline, Sajikumar, Sreedharan, Lim, Chwee Teck, Ffrench-Constant, Charles, Bechler, Marie E., Chew, Sing Yian
Published 2020

Loss of Caᵥ1.3 RNA editing enhances mouse hippocampal plasticity, learning, and memory

by Zhai, Jing, Navakkode, Sheeja, Yeow, Sean Qing Zhang, Krishna-K, Kumar, Liang, Mui Cheng, Koh, Joanne Huifen, Wong, Rui Xiong, Yu, Wei Ping, Sajikumar, Sreedharan, Huang, Hua, Soong, Tuck Wah
Published 2023

Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease

by Varma, Vijay RR, Desai, Rishi JJ, Navakkode, Sheeja, Wong, Lik-Wei, Anerillas, Carlos, Loeffler, Tina, Schilcher, Irene, Mahesri, Mufaddal, Chin, Kristyn, Horton, Daniel BB, Kim, Seoyoung CC, Gerhard, Tobias, Segal, Jodi BB, Schneeweiss, Sebastian, Gorospe, Myriam, Sajikumar, Sreedharan, Thambisetty, Madhav
Published 2023

Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and...

by Singh, Akash K., Neo, Sin H., Liwang, Christine, Pang, Karen K. L., Leng, Jason C. K., Sinha, Sarmistha H., Shetty, Mahesh S., Vasudevan, Madavan, Rao, Vinay J., Joshi, Ila, Eswaramoorthy, Muthusamy, Pavon, Maria V., Sheila, Ang R., Navakkode, Sheeja, Kundu, Tapas K., Sajikumar, Sreedharan
Published 2023