Loss of Caᵥ1.3 RNA editing enhances mouse hippocampal plasticity, learning, and memory

Loss of Caᵥ1.3 RNA editing enhances mouse hippocampal plasticity, learning, and memory

L-type CaV1.3 calcium channels are expressed on the dendrites and soma of neurons, and there is a paucity of information about its role in hippocampal plasticity. Here, by genetic targeting to ablate CaV1.3 RNA editing, we demonstrate that unedited CaV1.3ΔECS mice exhibited improved learning and enh...

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Bibliographic Details
Main Authors: Zhai, Jing, Navakkode, Sheeja, Yeow, Sean Qing Zhang, Krishna-K, Kumar, Liang, Mui Cheng, Koh, Joanne Huifen, Wong, Rui Xiong, Yu, Wei Ping, Sajikumar, Sreedharan, Huang, Hua, Soong, Tuck Wah
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2023
Subjects:
Science::Biological sciences
RNA Editing
Hippocampal Plasticity
Online Access:https://hdl.handle.net/10356/164080
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/164080

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