Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons

Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons

The master epigenetic regulator lysine acetyltransferase (KAT) p300/CBP plays a pivotal role in neuroplasticity and cognitive functions. Recent evidence has shown that in several neurodegenerative diseases, including Alzheimer's disease (AD), the expression level and function of p300/CBP are se...

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Main Authors: Singh, Akash K., Neo, Sin H., Liwang, Christine, Pang, Karen K. L., Leng, Jason C. K., Sinha, Sarmistha H., Shetty, Mahesh S., Vasudevan, Madavan, Rao, Vinay J., Joshi, Ila, Eswaramoorthy, Muthusamy, Pavon, Maria V., Sheila, Ang R., Navakkode, Sheeja, Kundu, Tapas K., Sajikumar, Sreedharan
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2023
Subjects:
Science::Medicine
Acyltransferase
Hippocampus
Online Access:https://hdl.handle.net/10356/170808
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/170808

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