Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons

• Main Authors: Singh, Akash K., Neo, Sin H., Liwang, Christine, Pang, Karen K. L., Leng, Jason C. K., Sinha, Sarmistha H., Shetty, Mahesh S., Vasudevan, Madavan, Rao, Vinay J., Joshi, Ila, Eswaramoorthy, Muthusamy, Pavon, Maria V., Sheila, Ang R., Navakkode, Sheeja, Kundu, Tapas K., Sajikumar, Sreedharan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Acyltransferase; Hippocampus
• Online Access: https://hdl.handle.net/10356/170808
• Institution: Nanyang Technological University

The master epigenetic regulator lysine acetyltransferase (KAT) p300/CBP plays a pivotal role in neuroplasticity and cognitive functions. Recent evidence has shown that in several neurodegenerative diseases, including Alzheimer's disease (AD), the expression level and function of p300/CBP are se...