ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing A beta impairment of insulin signaling in an Alzheimer's disease mouse model

• Main Authors: Chan, Elizabeth S, Shetty, Mahesh Shivarama, Sajikumar, Sreedharan, Chen, Christopher, Soong, Tuck Wah, Wong, Boon-Seng
• Other Authors: PHYSIOLOGY
• Format: Article
• Language: English
• Published: NATURE PUBLISHING GROUP 2022
• Subjects: Science & Technology; Multidisciplinary Sciences; Science & Technology - Other Topics; AMYLOID PRECURSOR PROTEIN; HUMAN APOLIPOPROTEIN-E; PHOSPHODIESTERASE INHIBITOR ROLIPRAM; RECEPTOR SUBUNIT GLUR1; LONG-TERM POTENTIATION; SYNAPTIC PLASTICITY; AMPA RECEPTORS; TARGETED REPLACEMENT; BRAIN INSULIN; WATER MAZE
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/218889
• Institution: National University of Singapore

10.1038/srep26119