Largazole inhibits ocular angiogenesis by modulating the expression of VEGFR2 and p21

• Main Authors: Qiu, Beiying, Tan, Alison, Tan, Yu Zhi, Chen, Qi-Yin, Luesch, Hendrik, Wang, Xiaomeng
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Ocular Angiogenesis; Cyclodepsipeptide
• Online Access: https://hdl.handle.net/10356/154015
• Institution: Nanyang Technological University

Ocular angiogenic diseases, characterized by abnormal blood vessel formation in the eye, are the leading cause of blindness. Although Anti-VEGF therapy is the first-line treatment in the market, a substantial number of patients are refractory to it or may develop resistance over time. As uncontrolle...