Complement factor B mediates ocular angiogenesis through regulating the VEGF signaling pathway

• Main Authors: Murray, Hannah, Qiu, Beiying, Ho, Sze Yuan, Wang, Xiaomeng
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Complement Factor B; Angiogenesis
• Online Access: https://hdl.handle.net/10356/154019
• Institution: Nanyang Technological University

Complement factor B (CFB), a 95-kDa protein, is a crucial catalytic element of the alternative pathway (AP) of complement. After binding of CFB to C3b, activation of the AP depends on the proteolytic cleavage of CFB by factor D to generate the C3 convertase (C3bBb). The C3 convertase contains the ca...