Functional classification of super-large families of enzymes based on substrate binding pocket residues for biocatalysis and enzyme engineering applications

• Main Authors: Sirota, Fernanda L., Maurer-Stroh, Sebastian, Li, Zhi, Eisenhaber, Frank, Eisenhaber, Birgit
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Zinc-Dependent Alcohol Dehydrogenase; Sequence Alignment Conflict
• Online Access: https://hdl.handle.net/10356/154026
• Institution: Nanyang Technological University

Large enzyme families such as the groups of zinc-dependent alcohol dehydrogenases (ADHs), long chain alcohol oxidases (AOxs) or amine dehydrogenases (AmDHs) with, sometimes, more than one million sequences in the non-redundant protein database and hundreds of experimentally characterized enzymes are...