Active site CP-loop dynamics modulate substrate binding, catalysis, oligomerization, stability, over-oxidation and recycling of 2-Cys Peroxiredoxins

by Kamariah, Neelagandan, Eisenhaber, Birgit, Eisenhaber, Frank, Grüber, Gerhard
Published 2020

Molecular mechanism of the Escherichia coli AhpC in the function of a chaperone under heat-shock conditions

by Kamariah, Neelagandan, Eisenhaber, Birgit, Eisenhaber, Frank, Grüber, Gerhard
Published 2018

Essential role of the flexible linker on the conformational equilibrium of bacterial peroxiredoxin reductase for effective regeneration of peroxiredoxin

by Grüber, Gerhard, Kamariah, Neelagandan, Eisenhaber, Birgit, Eisenhaber, Frank
Published 2018

Structural modelling of the lumenal domain of human GPAA1, the metallo-peptide synthetase subunit of the transamidase complex, reveals zinc-binding mode and two flaps surrounding t...

by Su, Chinh Tran-To, Sinha, Swati, Eisenhaber, Birgit, Eisenhaber, Frank
Published 2021

xHMMER3x2: Utilizing HMMER3’s speed and HMMER2’s sensitivity and specificity in the glocal alignment mode for improved large-scale protein domain annotation

by Yap, Choon-Kong, Eisenhaber, Birgit, Eisenhaber, Frank, Wong, Wing-Cheong
Published 2016

dissectHMMER: a HMMER-based score dissection framework that statistically evaluates fold-critical sequence segments for domain fold similarity

by Wong, Wing-Cheong, Yap, Choon-Kong, Eisenhaber, Birgit, Eisenhaber, Frank
Published 2015

On the necessity of dissecting sequence similarity scores into segment-specific contributions for inferring protein homology, function prediction and annotation

by Wong, Wing-Cheong, Maurer-Stroh, Sebastian, Eisenhaber, Birgit, Eisenhaber, Frank
Published 2014

The first quarter century of the dense alignment surface transmembrane prediction method

by Cserző, Miklós, Eisenhaber, Birgit, Eisenhaber, Frank, Magyar, Csaba, Simon, István
Published 2024

Darkness in the human gene and protein function space : widely modest or absent illumination by the life science literature and the trend for fewer protein function discoveries sin...

by Sinha, Swati, Eisenhaber, Birgit, Jensen, Lars Juhl, Kalbuaji, Bharata, Eisenhaber, Frank
Published 2019

Transition steps in peroxide reduction and a molecular switch for peroxide robustness of prokaryotic peroxiredoxins

by Kamariah, Neelagandan, Sek, Mun Foong, Eisenhaber, Birgit, Eisenhaber, Frank, Grüber, Gerhard
Published 2018

About the dark corners in the gene function space of Escherichia coli remaining without illumination by scientific literature

by Tantoso, Erwin, Eisenhaber, Birgit, Sinha, Swati, Jensen, Lars Juhl, Eisenhaber, Frank
Published 2023

Did the early full genome sequencing of yeast boost gene function discovery?

by Tantoso, Erwin, Eisenhaber, Birgit, Sinha, Swati, Jensen, Lars Juhl, Eisenhaber, Frank
Published 2023

Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

by Baker, James Alexander, Wong, Wing-Cheong, Eisenhaber, Birgit, Warwicker, Jim, Eisenhaber, Frank
Published 2018

Functional classification of super-large families of enzymes based on substrate binding pocket residues for biocatalysis and enzyme engineering applications

by Sirota, Fernanda L., Maurer-Stroh, Sebastian, Li, Zhi, Eisenhaber, Frank, Eisenhaber, Birgit
Published 2022

Functional Classification of Super-Large Families of Enzymes Based on Substrate Binding Pocket Residues for Biocatalysis and Enzyme Engineering Applications

by Sirota, Fernanda L., Maurer-Stroh, Sebastian, Li, Zhi, Eisenhaber, Frank, Eisenhaber, Birgit
Published 2022

Beware of moving tagerts: reference proteome content fluctuates substantially over the years

by Sirota, Fernanda L., Batagov, Arsen, Schneider, Georg, Eisenhaber, Birgit, Eisenhaber, Frank, Maurer-Stroh, Sebastian
Published 2013

Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites

by Eisenhaber, Birgit, Sinha, Swati, Jadalanki, Chaitanya K., Shitov, Vladimir A., Tan, Qiao Wen, Sirota, Fernanda L., Eisenhaber, Frank
Published 2021

Effect of the additional cysteine 503 of vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit F (AhpF) and the mechanism of AhpF and subunit C ass...

by Toh, Yew Kwang, Shin, Joon, Balakrishna, Asha Manikkoth, Kamariah, Neelagandan, Grüber, Ardina, Eisenhaber, Frank, Eisenhaber, Birgit, Grüber, Gerhard
Published 2020

Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723

by Sinha, Swati, Nge, Choy-Eng, Leong, Chung Yan, Ng, Veronica, Crasta, Sharon, Goh, Falicia, Low, Kia-Ngee, Zhang, Huibin, Arumugam, Prakash, Lezhava, Alexander, Chen, Swaine L., Kanagasundaram, Yoganathan, Ng, Siew Bee, Eisenhaber, Frank, Eisenhaber, Birgit, Mohammad Alfatah
Published 2019

Identification and engineering of 32 membered antifungal macrolactone notonesomycins

by Goh, Falicia, Zhang, Mingzi M., Lim, Tian Ru, Low, Kia Ngee, Nge, Choy Eng, Heng, Elena, Yeo, Wan Lin, Sirota, Fernanda L., Crasta, Sharon, Tan, Zann, Ng, Veronica, Leong, Chung Yan, Zhang, Huibin, Lezhava, Alexander, Chen, Swaine L., Hoon, Shawn S., Eisenhaber, Frank, Eisenhaber, Birgit, Kanagasundaram, Yoganathan, Wong, Fong T., Ng, Siew Bee
Published 2021