On the necessity of dissecting sequence similarity scores into segment-specific contributions for inferring protein homology, function prediction and annotation

• Main Authors: Wong, Wing-Cheong, Maurer-Stroh, Sebastian, Eisenhaber, Birgit, Eisenhaber, Frank
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/103901; http://hdl.handle.net/10220/20043
• Institution: Nanyang Technological University

Background Protein sequence similarities to any types of non-globular segments (coiled coils, low complexity regions, transmembrane regions, long loops, etc. where either positional sequence conservation is the result of a very simple, physically induced pattern or rather integral sequence properti...