xHMMER3x2: Utilizing HMMER3’s speed and HMMER2’s sensitivity and specificity in the glocal alignment mode for improved large-scale protein domain annotation

Background: While the local-mode HMMER3 is notable for its massive speed improvement, the slower glocal-mode HMMER2 is more exact for domain annotation by enforcing full domain-to-sequence alignments. Since a unit of domain necessarily implies a unit of function, local-mode HMMER3 alone remains insu...

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Bibliographic Details
Main Authors: Yap, Choon-Kong, Eisenhaber, Birgit, Eisenhaber, Frank, Wong, Wing-Cheong
Other Authors: School of Computer Science and Engineering
Format: Article
Language:English
Published: 2016
Subjects:
Online Access:https://hdl.handle.net/10356/84677
http://hdl.handle.net/10220/41906
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Institution: Nanyang Technological University
Language: English