Active site CP-loop dynamics modulate substrate binding, catalysis, oligomerization, stability, over-oxidation and recycling of 2-Cys Peroxiredoxins

Active site CP-loop dynamics modulate substrate binding, catalysis, oligomerization, stability, over-oxidation and recycling of 2-Cys Peroxiredoxins

Peroxiredoxins (Prxs) catalyse the rapid reduction of hydrogen peroxide, organic hydroperoxide and peroxynitrite, using a fully conserved peroxidatic cysteine (CP) located in a conserved sequence Pxxx(T/S)xxCP motif known as CP-loop. In addition, Prxs are involved in cellular signaling pathways and...

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Bibliographic Details
Main Authors: Kamariah, Neelagandan, Eisenhaber, Birgit, Eisenhaber, Frank, Grüber, Gerhard
Other Authors: School of Computer Science and Engineering
Format: Article
Language:English
Published: 2020
Subjects:
Science::Biological sciences
Oxidative Stress
Redox Homeostasis
Online Access:https://hdl.handle.net/10356/142461
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/142461

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