Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

• Main Authors: Baker, James Alexander, Wong, Wing-Cheong, Eisenhaber, Birgit, Warwicker, Jim, Eisenhaber, Frank
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Amino Acid Distribution; Genome-wide Statistical Study
• Online Access: https://hdl.handle.net/10356/88052; http://hdl.handle.net/10220/44533
• Institution: Nanyang Technological University

Background: Transmembrane helices (TMHs) frequently occur amongst protein architectures as means for proteins to attach to or embed into biological membranes. Physical constraints such as the membrane’s hydrophobicity and electrostatic potential apply uniform requirements to TMHs and their flanking...