Effect of the additional cysteine 503 of vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit F (AhpF) and the mechanism of AhpF and subunit C assembling

• Main Authors: Toh, Yew Kwang, Shin, Joon, Balakrishna, Asha Manikkoth, Kamariah, Neelagandan, Grüber, Ardina, Eisenhaber, Frank, Eisenhaber, Birgit, Grüber, Gerhard
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Reactive Oxygen Species; Oxidative Stress
• Online Access: https://hdl.handle.net/10356/144527
• Institution: Nanyang Technological University

The vancomycin-resistant Enterococcus faecalis alkyl hydroperoxide reductase complex (AhpR) with its subunits AhpC (EfAhpC) and AhpF (EfAhpF) is of paramount importance to restore redox homeostasis. Therefore, knowledge about this defense system is essential to understand its antibiotic-resistance a...