Nontoxic antimicrobial cationic peptide nanoconstructs with bacteria-displaceable polymeric counteranions

• Main Authors: Pranantyo, Dicky, Raju, Cheerlavancha, Si, Zhangyong, Xu, Xiaofei, Pethe, Kevin, Kang, En-Tang, Chan-Park, Mary B.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Chemical engineering::Polymers and polymer manufacture; Electrostatic Nanoconstructs; Competitive Displacement
• Online Access: https://hdl.handle.net/10356/154040
• Institution: Nanyang Technological University

Antimicrobial peptides that target the integrity of bacterial envelopes can eradicate pathogens with little development of resistance, but they often inflict nonselective toxicity toward mammalian cells. The prevailing approach to optimize the selectivity of cationic peptides has been to modify thei...