Kv1.3 channel up-regulation in peripheral blood T lymphocytes of patients with multiple sclerosis

• Main Authors: Markakis, Ioannis, Charitakis, Ioannis, Beeton, Christine, Galani, Melpomeni, Repousi, Elpida, Aggeloglou, Stella, Sfikakis, Petros P., Pennington, Michael W., Chandy, Kanianthara George, Poulopoulou, Cornelia
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; T Cells; Potassium Channels
• Online Access: https://hdl.handle.net/10356/154070
• Institution: Nanyang Technological University

Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation. It is noteworthy that an accumulating body of in vivo and in vitro evid...