Precisely structured nitric-oxide-releasing copolymer brush defeats broad-spectrum catheter-associated biofilm infections in vivo

• Main Authors: Hou, Zheng, Wu, Yang, Xu, Chen, Reghu, Sheethal, Shang, Zifang, Chen, Jingjie, Pranantyo, Dicky, Marimuth, Kalisvar, De, Partha Pratim, Ng, Oon Tek, Pethe, Kevin, Kang, En-Tang, Li, Peng, Chan-Park, Mary B.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Chemical engineering::Polymers and polymer manufacture; Coating Materials; Infectious Diseases
• Online Access: https://hdl.handle.net/10356/154112
• Institution: Nanyang Technological University

Gram-negative bacteria cannot be easily eradicated by antibiotics and are a major source of recalcitrant infections of indwelling medical devices. Among various device-associated infections, intravascular catheter infection is a leading cause of mortality. Prior approaches to surface modification, s...