Atomic structure of, and valine binding to the regulatory ACT domain of the Mycobacterium tuberculosis Rel protein

• Main Authors: Shin, Joon, Singal, Bharti, Manimekalai, Malathy Sony Subramanian, Wei Chen, Ming, Ragunathan, Priya, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; ACT Domain; Mycobacterium tuberculosis
• Online Access: https://hdl.handle.net/10356/154271
• Institution: Nanyang Technological University

The stringent response, regulated by the bifunctional (p)ppGpp synthetase/hydrolase Rel in mycobacteria, is critical for long-term survival of the drug-tolerant dormant state of Mycobacterium tuberculosis. During amino acid starvation, MtRel senses a drop in amino acid concentration and synthesizes...