A chemical biology approach reveals a dependency of glioblastoma on biotin distribution

• المؤلفون الرئيسيون: Yoon, Jeehyun, Grinchuk, Oleg V., Kannan, Srinivasaraghavan, Ang, Melgious Jin Yan, Li, Zhenglin, Tay, Emmy Xue Yun, Lok, Ker Zhing, Lee, Bernice Woon Li, Chuah, You Heng, Chia, Kimberly, Tirado-Magallanes, Roberto, Liu, Chenfei, Zhao, Haonan, Hor, Jin Hui, Lim, Jhin Jieh, Benoukraf, Touati, Toh, Tan Boon, Chow, Edward Kai-Hua, Kovalik, Jean-Paul, Ching, Jianhong, Ng, Shi-Yan, Koh, Ming Joo, Liu, Xiaogang, Verma, Chandra Shekhar, Ong, Derrick Sek Tong
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Biological sciences; Receptor-Mediated Endocytosis; Gene-Expression
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/154365

Glioblastoma (GBM) is a uniformly lethal disease driven by glioma stem cells (GSCs). Here, we use a chemical biology approach to unveil previously unknown GBM dependencies. By studying sulconazole (SN) with anti-GSC properties, we find that SN disrupts biotin distribution to the carboxylases and his...