Facile anchoring mussel adhesive mimic tentacles on biodegradable polymer cargo carriers via self-assembly for microplastic-free cosmetics
Enhancing the deposition of fragrance delivery systems contained in personal care products on target surfaces is crucial for increasing the longevity of scent, efficiently utilizing expensive functional compounds and limiting the generation of microplastics in domestic waste water. In this work,...
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Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
2022
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/154755 |
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Institution: | Nanyang Technological University |
Language: | English |
Summary: | Enhancing the deposition of fragrance delivery systems contained in personal care
products on target surfaces is crucial for increasing the longevity of scent, efficiently
utilizing expensive functional compounds and limiting the generation of microplastics in
domestic waste water. In this work, we designed and synthesized a new type of
biomimetic macromolecules, chitosan-graft-L-lysine-L-DOPA (C-L-D), as a versatile
biodegradable adhesion promoter to facilitate the deposition of biodegradable
fragrance carriers on diverse surfaces including hair, cotton and skin. The C-L-D has
hyperbranched chain architecture with many oligopeptide adhesive tentacles, each
being a simple mimic of mussel adhesive proteins. It also exhibits unique amphiphilic
characteristic. As a result, it could be facilely anchored on cargo-loaded poly(lactic-co glycolic acid) nanoparticle surface via self-assembly in the particle preparation
process. The C-L-D-modified nanoparticles show significantly higher deposition
efficiencies than polyvinyl alcohol- and chitosan-coated particles when deposited on
the target surfaces in different aqueous media as the lysine and DOPA units are
capable of providing multi-noncovalent interactions, including electrostatic, polar,
hydrophobic interactions, and bidentate hydrogen bonds, with the target surfaces, and
possibly also inducing oxidative cross-linking. A much higher retention rate of the C-L D-modified nanoparticles on cotton surface is also observed after washing with a soap
solution, which could be attributed to the significant role played by bidentate hydrogen
bonds. These findings suggest that C-L-D is a versatile biodegradable adhesion
promoter and has the potential to be applied for various personal care applications and
beyond. |
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