Hydromagnesiation of 1,3-enynes by magnesium hydride for synthesis of tri- and tetra-substituted allenes

• Main Authors: Wang, Bin, Li, Yihang, Pang, Jia Hao, Watanabe, Kohei, Takita, Ryo, Chiba, Shunsuke
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Allenes; Enynes
• Online Access: https://hdl.handle.net/10356/154832
• Institution: Nanyang Technological University

A protocol for regio-controlled hydromagnesiation of 1,3-enynes was developed using magnesium hydride that is generated in situ by solvothermal treatment of sodium hydride (NaH) and magnesium iodide (MgI2 ) in THF. The resulting allenylmagnesium species could be converted into tri- and tetra-substit...