Transition-metal-free reductive functionalization of tertiary carboxamides and lactams for α-branched amine synthesis

Transition-metal-free reductive functionalization of tertiary carboxamides and lactams for α-branched amine synthesis

A new method for the synthesis of α-branched amines by reductive functionalization of tertiary carboxamides and lactams is described. The process relies on the efficient and controlled reduction of tertiary amides by a sodium hydride/sodium iodide composite, in situ treatment of the resulting anioni...

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Bibliographic Details
Main Authors: Ong, Derek Yiren, Fan, Dongyang, Dixon, Darren J., Chiba, Shunsuke
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Amines
Coupling Reactions
Online Access:https://hdl.handle.net/10356/154835
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/154835

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