Leaving group ability in nucleophilic aromatic amination by sodium hydride-lithium iodide composite

• المؤلفون الرئيسيون: Pang, Jia Hao, Ong, Derek Yiren, Watanabe, Kohei, Takita, Ryo, Chiba, Shunsuke
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Chemistry; Nucleophilic Amination; Concerted Aromatic Substitution
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/154838
• المؤسسة: Nanyang Technological University

The methoxy group is generally considered as a poor leaving group for nucleophilic substitution reactions. This work verified the superior ability of the methoxy group in nucleophilic amination of arenes mediated by the sodium hydride and lithium iodide through experimental and computational approac...