Nucleophilic amination of methoxypyridines by a sodium hydride-iodide composite

A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest.

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Bibliographic Details
Main Authors: Pang, Jia Hao, Kaga, Atsushi, Chiba, Shunsuke
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Online Access:https://hdl.handle.net/10356/139533
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Institution: Nanyang Technological University
Language: English