Diastereoselective intramolecular hydride transfer triggered by electrophilic halogenation of aryl alkenes

• Main Authors: Wang, Bin, Gandamana, Dhika Aditya, León Rayo, David Fabian, Gagosz, Fabien, Chiba, Shunsuke
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Tetrahydrofurans; Hydrocarbons
• Online Access: https://hdl.handle.net/10356/154839
• Institution: Nanyang Technological University

Diastereoselective hydride transfer could be triggered by electrophilic halogenation (bromination or fluorination) of homoallylic alcohol O-Bn ethers. The resulting diastereomerically enriched haloalkyl alcohols underwent subsequent intramolecular nucleophilic substitution to afford the correspondin...