Microfluidic size exclusion chromatography (μSEC) for extracellular vesicles and plasma protein separation

• Main Authors: Leong, Sheng Yuan, Ong, Hong Boon, Tay, Hui Min, Kong, Fang, Upadya, Megha, Gong, Lingyan, Dao, Ming, Dalan, Rinkoo, Hou, Han Wei
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Science::Medicine; Blood; Extracellular Vesicles
• Online Access: https://hdl.handle.net/10356/154936
• Institution: Nanyang Technological University

Extracellular vesicles (EVs) are recognized as next generation diagnostic bio-markers due to their disease-specific biomolecular cargoes and importance in cell–cell communications. A major bottleneck in EV sample preparation is the inefficient and laborious isolation of nanoscale EVs (≈50–200 nm) fr...