Carbene-catalyzed enantioselective hydrophosphination of α-bromoenals to prepare phosphine-containing chiral molecules

• Main Authors: Maiti, Rakesh, Yan, Jia-Lei, Yang, Xing, Mondal, Bivas, Xu, Jun, Chai, Huifang, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Asymmetric Hydrophosphination; Chiral Phosphine
• Online Access: https://hdl.handle.net/10356/155058
• Institution: Nanyang Technological University

Disclosed herein is the first carbene-organocatalyzed asymmetric addition of phosphine nucleophiles to the in situ generated α,β-unsaturated acyl azolium intermediates. Our reaction enantioselectively constructs carbon-phosphine bonds and prepares chiral phosphines with high optical purities. The ph...