Carbene-catalyzed asymmetric construction of atropisomers

Atropisomeric molecules have found proven applications and have shown promising potential in chemistry and medicine. The design of N-heterocyclic carbene (NHC) catalyzed reactions to construct atropisomerically enriched molecules has emerged as an important research topic in recent years. These reac...

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Main Authors: Song, Runjiang, Xie, Yongtao, Jin, Zhichao, Chi, Robin Yonggui
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/155059
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1550592022-02-22T08:53:24Z Carbene-catalyzed asymmetric construction of atropisomers Song, Runjiang Xie, Yongtao Jin, Zhichao Chi, Robin Yonggui School of Physical and Mathematical Sciences Science::Chemistry Atropisomers Cycloaddition Atropisomeric molecules have found proven applications and have shown promising potential in chemistry and medicine. The design of N-heterocyclic carbene (NHC) catalyzed reactions to construct atropisomerically enriched molecules has emerged as an important research topic in recent years. These reactions include kinetic resolutions, asymmetric desymmetrizations, central-to-axial chirality conversions, and cycloadditions. This Minireview evaluates and summarizes the progress in NHC-based organic catalysis for access to atropisomers, and briefly states our personal perspectives on the future advancement of this topic. NHC catalysis has provided rich and unique reaction modes that have led to success in the asymmetric synthesis of central-chiral molecules. It is expected that similar success could also be achieved in developing NHC catalysis to prepare atropisomeric molecules, including those not easily accessible by other methods. We acknowledge financial support from the Program of Introducing Talents of Discipline to Universities of China (111 Program, D20023) at Guizhou University, Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules, Department of Education, Guizhou Province [Qianjiaohe KY (2020) 004], the Basicand Applied Research Foundation of Guangdong Province (2019A1515110906), and the Guizhou Province First-Class Disciplines Project [(Yiliu Xueke Jianshe Xiangmu)-GNYL(2017)008]. 2022-02-22T08:53:24Z 2022-02-22T08:53:24Z 2021 Journal Article Song, R., Xie, Y., Jin, Z. & Chi, R. Y. (2021). Carbene-catalyzed asymmetric construction of atropisomers. Angewandte Chemie International Edition, 60(50), 26026-26037. https://dx.doi.org/10.1002/anie.202108630 1433-7851 https://hdl.handle.net/10356/155059 10.1002/anie.202108630 34270158 2-s2.0-85112219218 50 60 26026 26037 en Angewandte Chemie International Edition © 2021 Wiley-VCHGmbH. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Atropisomers
Cycloaddition
spellingShingle Science::Chemistry
Atropisomers
Cycloaddition
Song, Runjiang
Xie, Yongtao
Jin, Zhichao
Chi, Robin Yonggui
Carbene-catalyzed asymmetric construction of atropisomers
description Atropisomeric molecules have found proven applications and have shown promising potential in chemistry and medicine. The design of N-heterocyclic carbene (NHC) catalyzed reactions to construct atropisomerically enriched molecules has emerged as an important research topic in recent years. These reactions include kinetic resolutions, asymmetric desymmetrizations, central-to-axial chirality conversions, and cycloadditions. This Minireview evaluates and summarizes the progress in NHC-based organic catalysis for access to atropisomers, and briefly states our personal perspectives on the future advancement of this topic. NHC catalysis has provided rich and unique reaction modes that have led to success in the asymmetric synthesis of central-chiral molecules. It is expected that similar success could also be achieved in developing NHC catalysis to prepare atropisomeric molecules, including those not easily accessible by other methods.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Song, Runjiang
Xie, Yongtao
Jin, Zhichao
Chi, Robin Yonggui
format Article
author Song, Runjiang
Xie, Yongtao
Jin, Zhichao
Chi, Robin Yonggui
author_sort Song, Runjiang
title Carbene-catalyzed asymmetric construction of atropisomers
title_short Carbene-catalyzed asymmetric construction of atropisomers
title_full Carbene-catalyzed asymmetric construction of atropisomers
title_fullStr Carbene-catalyzed asymmetric construction of atropisomers
title_full_unstemmed Carbene-catalyzed asymmetric construction of atropisomers
title_sort carbene-catalyzed asymmetric construction of atropisomers
publishDate 2022
url https://hdl.handle.net/10356/155059
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