Carbene-catalyzed enantioselective annulation of dinucleophilic hydrazones and bromoenals for access to aryl-dihydropyridazinones and related drugs

• Main Authors: Mondal, Bivas, Maiti, Rakesh, Yang, Xing, Xu, Jun, Tian, Weiyi, Yan, Jia-Lei, Li, Xiangyang, Chi, Robin Yonggui
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Science::Chemistry; Molecules; Reaction Intermediates
• 在線閱讀: https://hdl.handle.net/10356/155061
• 機構: Nanyang Technological University

4,5-Dihydropyridazinones bearing an aryl substituent at the C6-position are important motifs in drug molecules. Herein, we developed an efficient protocol to access aryl-dihydropyridazinone molecules via carbene-catalyzed asymmetric annulation between dinucleophilic arylidene hydrazones and bromoena...