Carbene-catalyzed enantioselective annulation of dinucleophilic hydrazones and bromoenals for access to aryl-dihydropyridazinones and related drugs

• المؤلفون الرئيسيون: Mondal, Bivas, Maiti, Rakesh, Yang, Xing, Xu, Jun, Tian, Weiyi, Yan, Jia-Lei, Li, Xiangyang, Chi, Robin Yonggui
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Chemistry; Molecules; Reaction Intermediates
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/155061
• المؤسسة: Nanyang Technological University

4,5-Dihydropyridazinones bearing an aryl substituent at the C6-position are important motifs in drug molecules. Herein, we developed an efficient protocol to access aryl-dihydropyridazinone molecules via carbene-catalyzed asymmetric annulation between dinucleophilic arylidene hydrazones and bromoena...