Carbene-catalyzed atroposelective annulation and desymmetrization of urazoles

• Main Authors: Jin, Jiamiao, Huang, Xuan, Xu, Jun, Li, Tingting, Peng, Xiaolin, Zhu, Xun, Zhang, Junmin, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Chirality; Chemical Reactions
• Online Access: https://hdl.handle.net/10356/155071
• Institution: Nanyang Technological University

An NHC-catalyzed atroposelective reaction between ynals and urazoles is disclosed. The reaction establishes a chiral C-N axis via an atroposelective [3 + 2] annulation/desymmetrization process. Our reaction allows efficient access to axially chiral and heteroatom-rich urazole derivatives with potent...