N-heterocyclic carbene-catalyzed atroposelective annulation for access to thiazine derivatives with C-N axial chirality

• المؤلفون الرئيسيون: Li, Tingting, Mou, Chengli, Qi, Puying, Peng, Xiaolin, Jiang, Shichun, Hao, Gefei, Xue, Wei, Yang, Song, Hao, Lin, Chi, Robin Yonggui, Jin, Zhichao
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science; Atroposelective Reaction; Chiral C-N Axis
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/148217
• المؤسسة: Nanyang Technological University

A catalytic atroposelective cycloaddition reaction between thioureas and ynals is developed. This reaction features the first NHC-catalyzed addition of thioureas to acetylenic acylazolium intermediates to eventually set up C-N axial chirality with excellent optical purities. The obtained axially chi...