Carbene-catalyzed direct O-functionalization of ketone: atroposelective access to non-C₂-symmetric binaphthyls

• Main Authors: Mondal, Bivas, Chen, Hang, Maiti, Rakesh, Wang, Hongling, Cai, Hui, Mou, Chengli, Hao, Lin, Chai, Huifang, Chi, Robin Yonggui
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Ketone; Atroposelective Access
• Online Access: https://hdl.handle.net/10356/173356
• Institution: Nanyang Technological University

Disclosed here is NHC-catalyzed direct intermolecular trapping of the ketone oxygen atom with the acyl azolium intermediate. The overall reaction is a dynamic kinetic resolution process that converts ketone to the corresponding enol ester with well-controlled axial chirality. Our reaction eventually...