N-heterocyclic carbene-catalyzed atroposelective annulation for access to thiazine derivatives with C-N axial chirality

• Main Authors: Li, Tingting, Mou, Chengli, Qi, Puying, Peng, Xiaolin, Jiang, Shichun, Hao, Gefei, Xue, Wei, Yang, Song, Hao, Lin, Chi, Robin Yonggui, Jin, Zhichao
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science; Atroposelective Reaction; Chiral C-N Axis
• Online Access: https://hdl.handle.net/10356/148217
• Institution: Nanyang Technological University

A catalytic atroposelective cycloaddition reaction between thioureas and ynals is developed. This reaction features the first NHC-catalyzed addition of thioureas to acetylenic acylazolium intermediates to eventually set up C-N axial chirality with excellent optical purities. The obtained axially chi...