Asymmetric three-component Heck arylation/amination of nonconjugated cyclodienes

Asymmetric three-component Heck arylation/amination of nonconjugated cyclodienes

Substituted cyclohexylamines are becoming increasingly important in drug discovery. Asymmetric Heck insertion/amination of nonconjugated cyclodienes proceeds to give 5-aryl cyclohexenylamines with good enantioselectivity and exclusive trans configurations. Primary and secondary anilines, indoline, a...

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Bibliographic Details
Main Authors: Zhu, Daoyong, Jiao, Zhiwei, Chi, Robin Yonggui, Gonçalves, Théo P., Huang, Kuo-Wei, Zhou, Steve Jianrong
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Allylic Amination
Phosphites
Online Access:https://hdl.handle.net/10356/155084
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Institution: Nanyang Technological University
Language: English
Description
Summary:Substituted cyclohexylamines are becoming increasingly important in drug discovery. Asymmetric Heck insertion/amination of nonconjugated cyclodienes proceeds to give 5-aryl cyclohexenylamines with good enantioselectivity and exclusive trans configurations. Primary and secondary anilines, indoline, and benzylamines are suitable amines. The weakly donating diphosphite Kelliphite forms a deep unsymmetrical pocket, which is essential for stereoselective anti attack of amines.

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