Asymmetric reductive and alkynylative heck bicyclization of enynes to access conformationally restricted aza[3.1.0]bicycles

• Main Authors: Huang, Xiaolei, Nguyen, Minh Hieu, Pu, Maoping, Zhang, Luoqiang, Chi, Robin Yonggui, Wu, Yun-Dong, Zhou, Steve Jianrong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Alkynylation; Azabicycles
• Online Access: https://hdl.handle.net/10356/155086
• Institution: Nanyang Technological University

Conformationally restricted azabicycles are becoming increasingly important in medicinal research. Asymmetric Heck bicyclization of enynes proceeds to give medicinally useful aza[3.1.0] and aza[4.1.0] bicycles with excellent enantioselectivity. The key organopalladium species after bicyclization can...