Enantioselective intermolecular Heck and reductive Heck reactions of aryl triflates, mesylates, and tosylates catalyzed by nickel

• Main Authors: Huang, Xiaolei, Teng, Shenghan, Chi, Robin Yonggui, Xu, Wenqiang, Pu, Maoping, Wu, Yun-Dong, Zhou, Steve Jianrong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science; Aryl Halides; Heck Reaction
• Online Access: https://hdl.handle.net/10356/148218
• Institution: Nanyang Technological University

Nickel-catalyzed intermolecular Heck reaction of cycloalkenes proceeds well with aryl triflates, mesylates and tosylates in excellent enantiomeric ratios. The asymmetric reductive Heck reaction also works with a 2-cyclopentenone ketal, which is equivalent to conjugate arylation of the enone itself.