Patterning of oncogenic Ras clustering in live cells using vertically aligned nanostructure arrays

• Main Authors: Mu, Huanwen, Zeng, Yongpeng, Zhuang, Yinyin, Gao, Weibo, Zhou, Yong, Rajalingam, Krishnaraj, Zhao, Wenting
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Chemical engineering; Nanobar; Ras Oncogene
• Online Access: https://hdl.handle.net/10356/155186
• Institution: Nanyang Technological University

As a dominant oncogenic protein, Ras is well-known to segregate into clusters on the plasma membrane for activating downstream signaling. However, current technologies for direct measurements of Ras clustering are limited to sophisticated high-resolution techniques like electron microscopy and fluor...