Modular design of a hybrid hydrogel for protease-triggered enhancement of drug delivery to regulate TNF-α production by pro-inflammatory macrophages

• Main Authors: Nguyen, Dang Tri, Soeranaya, Bob Hartadhi Tji, Truong, Thi Hong Anh, Dang, Tram Thuy
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Bioengineering; Matrix-Metalloprotease-9; Hydrogel
• Online Access: https://hdl.handle.net/10356/155231
• Institution: Nanyang Technological University

Systemic drug administration has conventionally been prescribed to alleviate persistent local inflammation which is prevalent in chronic diseases. However, this approach is associated with drug-induced toxicity, particularly when the dosage exceeds that necessitated by pathological conditions of dis...