Modular design of a hybrid hydrogel for protease-triggered enhancement of drug delivery to regulate TNF-α production by pro-inflammatory macrophages

• المؤلفون الرئيسيون: Nguyen, Dang Tri, Soeranaya, Bob Hartadhi Tji, Truong, Thi Hong Anh, Dang, Tram Thuy
• مؤلفون آخرون: School of Chemical and Biomedical Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Engineering::Bioengineering; Matrix-Metalloprotease-9; Hydrogel
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/155231

Systemic drug administration has conventionally been prescribed to alleviate persistent local inflammation which is prevalent in chronic diseases. However, this approach is associated with drug-induced toxicity, particularly when the dosage exceeds that necessitated by pathological conditions of dis...