Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA

Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA

Terpolymers are used to generate bio-decomposable self-assemblies. PEG-PVL-PGMA terpolymers are synthesized via a combination of organocatalyzed living radical polymerization (RCMP) with polymerization-induced self-assembly (PISA), generating vesicle, multicompartment micelle (MCM), and core-compart...

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Bibliographic Details
Main Authors: Sarkar, Jit, Lim, Ying Faye, Goto, Atsushi
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Bio-Decomposability
Higher-Order Assemblie
Online Access:https://hdl.handle.net/10356/155587
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Institution: Nanyang Technological University
Language: English
Description
Summary:Terpolymers are used to generate bio-decomposable self-assemblies. PEG-PVL-PGMA terpolymers are synthesized via a combination of organocatalyzed living radical polymerization (RCMP) with polymerization-induced self-assembly (PISA), generating vesicle, multicompartment micelle (MCM), and core-compartmentalized worm (CCW), where PEG, PVL, and PGMA are poly(ethylene glycol) monomethyl ether, poly(δ-valerolactone), and poly(glycidyl methacrylate) and PGMA is grown during the PISA. MCM and CCW are uniquely obtainable using terpolymers. The PVL segment is biodegradable, and the obtained assemblies are bio-decomposable. Heavy metal-free and sulfur-free synthesis and bio-decomposability of the assemblies are attractive features.

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