Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA

Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA

Terpolymers are used to generate bio-decomposable self-assemblies. PEG-PVL-PGMA terpolymers are synthesized via a combination of organocatalyzed living radical polymerization (RCMP) with polymerization-induced self-assembly (PISA), generating vesicle, multicompartment micelle (MCM), and core-compart...

Full description

Saved in:
Bibliographic Details
Main Authors: Sarkar, Jit, Lim, Ying Faye, Goto, Atsushi
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Bio-Decomposability
Higher-Order Assemblie
Online Access:https://hdl.handle.net/10356/155587
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-155587
record_format dspace
spelling sg-ntu-dr.10356-1555872023-02-28T20:06:28Z Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA Sarkar, Jit Lim, Ying Faye Goto, Atsushi School of Physical and Mathematical Sciences Science::Chemistry Bio-Decomposability Higher-Order Assemblie Terpolymers are used to generate bio-decomposable self-assemblies. PEG-PVL-PGMA terpolymers are synthesized via a combination of organocatalyzed living radical polymerization (RCMP) with polymerization-induced self-assembly (PISA), generating vesicle, multicompartment micelle (MCM), and core-compartmentalized worm (CCW), where PEG, PVL, and PGMA are poly(ethylene glycol) monomethyl ether, poly(δ-valerolactone), and poly(glycidyl methacrylate) and PGMA is grown during the PISA. MCM and CCW are uniquely obtainable using terpolymers. The PVL segment is biodegradable, and the obtained assemblies are bio-decomposable. Heavy metal-free and sulfur-free synthesis and bio-decomposability of the assemblies are attractive features. National Research Foundation (NRF) Accepted version This work was supported by the National Research Foundation (NRF) Investigatorship in Singapore (NRF-NRFI05-2019-0001). 2022-03-08T08:42:35Z 2022-03-08T08:42:35Z 2021 Journal Article Sarkar, J., Lim, Y. F. & Goto, A. (2021). Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA. Macromolecular Chemistry and Physics, 222(24), 2100349-. https://dx.doi.org/10.1002/macp.202100349 1022-1352 https://hdl.handle.net/10356/155587 10.1002/macp.202100349 2-s2.0-85119061788 24 222 2100349 en NRF-NRFI05-2019-0001 Macromolecular Chemistry and Physics This is the peer reviewed version of the following article: Sarkar, J., Lim, Y. F. & Goto, A. (2021). Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA. Macromolecular Chemistry and Physics, 222(24), 2100349-, which has been published in final form at https://doi.org/10.1002/macp.202100349. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Bio-Decomposability
Higher-Order Assemblie
spellingShingle Science::Chemistry
Bio-Decomposability
Higher-Order Assemblie
Sarkar, Jit
Lim, Ying Faye
Goto, Atsushi
Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA
description Terpolymers are used to generate bio-decomposable self-assemblies. PEG-PVL-PGMA terpolymers are synthesized via a combination of organocatalyzed living radical polymerization (RCMP) with polymerization-induced self-assembly (PISA), generating vesicle, multicompartment micelle (MCM), and core-compartmentalized worm (CCW), where PEG, PVL, and PGMA are poly(ethylene glycol) monomethyl ether, poly(δ-valerolactone), and poly(glycidyl methacrylate) and PGMA is grown during the PISA. MCM and CCW are uniquely obtainable using terpolymers. The PVL segment is biodegradable, and the obtained assemblies are bio-decomposable. Heavy metal-free and sulfur-free synthesis and bio-decomposability of the assemblies are attractive features.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Sarkar, Jit
Lim, Ying Faye
Goto, Atsushi
format Article
author Sarkar, Jit
Lim, Ying Faye
Goto, Atsushi
author_sort Sarkar, Jit
title Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA
title_short Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA
title_full Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA
title_fullStr Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA
title_full_unstemmed Synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using RCMP-PISA
title_sort synthesis of biologically decomposable terpolymer nanocapsules and higher-order nanoassemblies using rcmp-pisa
publishDate 2022
url https://hdl.handle.net/10356/155587
_version_ 1759855145087139840

Similar Items