Biosynthesis of tasikamides via pathway coupling and diazonium-mediated hydrazone formation

• Main Authors: Ma, Guang-Lei, Candra, Hartono, Pang, Li Mei, Xiong, Juan, Ding, Yichen, Tran, Hoa Thi, Low, Zhen Jie, Ye, Hong, Liu, Min, Zheng, Jie, Fang, Mingliang, Cao, Bin, Liang, Zhao-Xun
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Medicine, Health and Life Sciences; Biosynthesis; Natural Product; Enzyme; Peptide
• 在線閱讀: https://hdl.handle.net/10356/155779

Naturally occurring hydrazones are rare despite the ubiquitous usage of synthetic hydrazones in the preparation of organic compounds and functional materials. In this study, we discovered a family of novel microbial metabolites (tasikamides) that share a unique cyclic pentapeptide scaffold. Surpri...