Pathway retrofitting yields insights into the biosynthesis of anthraquinone-fused enediynes

• Main Authors: Ma, Guang-Lei, Tran, Hoa Thi, Low, Zhen Jie, Candra, Hartono, Pang, Li Mei, Cheang, Qing Wei, Fang, Mingliang, Liang, Zhao-Xun
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Medicine, Health and Life Sciences; Biosynthesis; Natural Product; Enzyme; Synthetic Biology
• Online Access: https://hdl.handle.net/10356/155780
• Institution: Nanyang Technological University

Anthraquinone-fused enediynes (AQEs) are renowned for their distinctive molecular architecture, reactive enediyne warhead, and potent anticancer activity. Although the first members of AQEs, i.e., dynemicins, were discovered three decades ago, how their nitrogen-containing carbon skeleton is sy...